Looking at a map of Prague a blue question mark runs through the middle of the city. That is the river Vltava. Further one can notice that Prague is a city which has organically developed since the middle ages; there is no evident urban planning but a lively random sprawl of quarters and streets.
By the way, it is great to get lost in a city if one has time, since more often than not one will then find those little secluded gems where one would not have looked otherwise.
If you prefer to reach places in the allotted time, try to orientate yourself by the different parts of Prague. Right in the center of the city are Malá Strana, Lesser Town, Staré Mesto, Old Town, they are divided by the Vltava River. Clinging to Staré Mesto in the north is Josefov, the Jewish quarter of Prague.
Just south of the river bend is the tight cluster of Hradcany, the medieval castle district and thus the oldest part of Prague. Nové Mesto is the New Town complex located south of Staré Mesto.
An interesting virtual trip and a fun way to familiarize oneself with Prague, is provided by the online map of Prague on www.mapy.cz. The small pictures show you nearby sights.
Czech Link: City map on mapy.cz…